The organoids Paula created in the lab are tiny. Compared to the real brain, it is much simpler and less complicated.

‘Brain Organoid ‘. In simple English, it means a group of brain cells. But the specialty of the organoid is that it is a three-dimensional cell structure made in the lab. The cells that are usually cultured in the laboratory are two dimensional cells. Italian scientist Paola Arlotta has created a three-dimensional brain organoid from human stem cells at Harvard University’s laboratory. The shape is like an apple seed, or raisins. These cells are small but visible to the naked eye. Scientists claim that this brain organoid made in the laboratory is working exactly like the human brain. “I can’t describe how I feel! When a child grows little by little in the womb of the mother, many cells are formed from one cell, we do not see that process. In the lab, I can see cells forming. “

The organoids Paula created in the lab are tiny. Compared to the real brain, it is much simpler and less complicated. But in this way, seeing multiple cells being made from one cell in the laboratory, the growth of nerve cells together, being equipped with the circuit as it happens in real life – all these amazed the scientists. They say that this time they can see a glimpse of the way the human brain is formed in the mother’s womb. The first chapter of the mystery of life is unfolding little by little.

Many scientists around the world are researching on organoids. Paul is one of them. “We’ve never seen anything like this before. I see how cells are made. The cells of mice or any other animal cannot be examined in such detail. We can work with humans on this. ” Paula is a professor of stem cell and regenerative biology at Harvard and a member of the Stanley Center for Psychiatric Research at MIT.

Paula created the organoid on the model of the cerebral cortex. This part of the brain breathes language into people’s mouths, stores memories, explains the cause of an event, expresses feelings, decision-making abilities, personality. Because of the disturbances in this part of the brain, diseases like autism, schizophrenia, dementia occur. In her research, Paula is investigating what exactly happens in the cerebral cortex, which causes such a disease. He’s also looking for ways to find a cure.

Read More News: Breast cancer: Scientists look at ways to reconstruct organs

For example, Paula’s research will help determine what kind of cells are damaged in the brain of an autistic child. Having a child with autism means that the disorder began to take root before he or she was born. Scientists believe that it begins in the first weeks of pregnancy. “We can’t go back to the time when a child with autism was in the womb looking for a cure,” Paula said. That time has gone. ” What Paula is doing now is this: The patient’s blood or skin samples have been collected and converted into stem cells. Organoids are made from it. In this case, each cell carries the gene of the patient. In this way, scientists are able to detect gene defects during the formation of a cell from a cell. “It’s like watching a movie from scratch,” Paula said. We will find out where it has gone. No one knew why this was happening. We are trying to understand everything. The black box is opened. “

This news is a creative derivative product from articles published in famous peer-reviewed journals and Govt reports:

1. Arrieta AB, Díaz-Rodríguez N, Del Ser J, Bennetot A, Tabik S, Barbado A, Herrera F (2020) Explainable Artificial Intelligence (XAI): concepts, taxonomies, opportunities and challenges toward responsible AI. Inform Fusion 58:82–115
2. Bibal A, Lognoul M, De Streel A, Frénay B (2021) Legal requirements on explainability in machine learning. Artif Intell Law 29(2):149–169
3. Bonezzi A, Ostinelli M, Melzner J (2022) The human black-box: the illusion of understanding human better than algorithmic decision-making. J Exp Psychol Gen 151(9):2250–2258.
4. Brożek B, Hage J, Vincent N (eds) (2021) Law and mind: a Survey of Law and the Cognitive Sciences. Cambridge University Press, Cambridge.

By Editor

Leave a Reply