The following study aims to investigate the prolongation of the QTc interval in individuals diagnosed with Diabetic Ketoacidosis, with a focus on electrolyte imbalances. Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are two dangerous manifestations of diabetes mellitus representing the extremes in the spectrum of uncontrolled diabetic states. DKA occurs primarily in individuals with type 1 diabetes, and the basic defect in its pathogenesis is insulin deficiency. DKA accounts for 14 percent of all hospital admissions among diabetics and 16 percent of all diabetes-related fatalities in India. The study was conducted in the ICU, general medicine ward, and casualty under the Department of Medicine at a tertiary care hospital from August 2020 to July 2022. The present study found that the maximum mean ± SD of QTc in the electrolyte abnormal group was 441.11 ± 16.49, and in the electrolyte normal group, it was 424.41 ± 21.30. The minimum mean ± SD of QTc in the electrolyte abnormal group was 393.69 ± 8.24, and in the electrolyte normal group, it was 383.08 ± 15.99. The dispersion mean ± SD of QTc in the electrolyte abnormal group was 48.75 ± 9.22, and in the electrolyte normal group, it was 41.63 ± 9.88. The mean mean ± SD of QTc in the electrolyte abnormal group was 417.41 ± 12.35, and in the electrolyte normal group, it was 404.65 ± 15.81. HbA1c levels were found to be between 7 to 10 in 77 percent of cases and >10 in 23 percent of cases. In Group A, the HbA1c mean ± SD was 9.2 ± 0.41, and in Group B, it was 9.6 ± 0.605. The study found a statistically significant correlation between HbA1c and QTc interval prolongation. It is suggested that QTc interval prolongation is an indicator of Cardiac Autonomic Neuropathy (CAN) and a predictive tool for cardiovascular mortality (worse outcomes) in patients with Diabetic Ketoacidosis.
Author(s) Details:
Manjiri R. Naik,
Department of Medicine, MGM Medical College and Hospital, Aurangabad, India.
Shamisha Khade,
Department of Medicine, MGM Medical College and Hospital, Aurangabad, India.
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