asymptomatic PBC

Comorbid primary biliary cholangitis (PBC) and systemic lupus erythematosus (SLE) are rare. Therefore, this study conducted a literature search and reviewed published studies involving patients with comorbid SLE and PBC.

The study found that among the 27 patients with comorbid PBC and SLE, 96.3% (26/27) were women. 62.5% (15/24) were initially diagnosed with PBC, and three patients were diagnosed with both SLE and PBC almost simultaneously.

Sjögren’s syndrome was the most common autoimmune complication associated with comorbid SLE and PBC (18.5% and 5/27). Immune thrombocytopenia was diagnosed in two patients (7.4%). Additionally, two patients had familial PBC.

Three patients died, including two elderly patients with liver failure due to worsening PBC and one with an unknown cause of death.

Author(s) Details:

Toru Shizuma,
Department of Physiology, Tokai University School of Medicine, Japan.

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