The journey after mastectomy is also not smooth for those who have been diagnosed with breast cancer or are at risk of getting infected.
That was decades ago. Angelina Jolie is one of the most famous actresses in Hollywood. A genetic test revealed the presence of the Brac-1 gene in her body. Jolie’s mother died of ovarian cancer at the age of 56. Keeping these two things in mind, the doctors said that Jolie’s cancer was almost inevitable. Jolie underwent a prophylactic double mastectomy in 2013. Two breasts were surgically removed. The word ‘mastectomy’ has been introduced to the world. The actress revealed this in front of the media. The aim was to create awareness among women. This has happened in the past decade. Medical science is also advancing at a rapid pace. A group of scientists at the National Cancer Institute (NCI) in the United States have claimed that they have found a way to reconstruct the breast after mastectomy. They are creating mammary glands in the laboratory, which will work like real human organs.
The journey after mastectomy is also not smooth for those who have been diagnosed with breast cancer or are at risk of getting infected. Doctors say that sometimes the breast is created artificially by taking cells from the patient’s body, sometimes silicone gel is used. But it never really works like that. The scientists at NCI said they have created miniature mammary glands in the lab using mouse embryo cells. Laboratory tests showed the tiny organ behaved like a breast and even released milk under the influence of hormones, they said. The team is led by NCI researchers Shaunak Sahu and Shyam Saran. The study was published in the journal Developmental Cell.
Scientists say that not only cancer, but many changes occur in the body of women due to the influence of hormones during pregnancy, many breast disorders occur. Their research can show the way to treatment in all these cases. Shaunak said that the TBX3 gene mutation is responsible for the ‘ulnar mammary syndrome’. In this disease the breasts do not develop properly. Scientists say that with the help of their developed model, a solution can also be found in this case. He said the creation of organoids in the laboratory is a revolution in medical science. With this, on the one hand, it will be possible to replace the damaged cells of the body, on the other hand, specific treatment (personalized treatment) will be found in the patient. ‘Regenerative medicine ‘(reconstruction of human cells and keeping their function intact) can also be developed. Also, if someone like Jolie has a mutation in the Braca gene, the organoids will be able to confirm whether or not she will actually develop cancer in the future. Although the study was successful in animal trials, human trials are still pending. “In our therapy, the mammary gland will be reconstructed from the patient’s cells. As a result, there is less fear of ‘immune rejection’ in the human body. ”